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Metabolism of colchicine in vivo has not been fully investigated in humans niel and scherrmann, 2006 , but the in vitro experiments have demonstrated that colchicine undergoes same oxidative demethylation in both human and rat liver microsomes tateishi et al.

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Identification of colchicine metabolites in rat bile.

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Signs and symptoms of colchicine toxicity should be evaluated promptly and, if toxicity is suspected, mitigare should be discontinued immediately.

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Other drugs that may increase methotrexate toxicity include barbiturates, proton pump inhibitors pantoprazole, omeprazole, esomeprazole, lansoprazole, rabeprazole , colchicine, dipyridamol, phenytoin, sulfonylureas, frusemide furosemide and thiazide diuretics.

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